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Congenital and Inherited Disorders of the Urinary System in Dogs
date February 3, 2025
Certain urinary tract abnormalities are inherited or congenital (present at birth). These abnormalities are caused by abnormal genes or produced by injury, disease, or exposure to toxic substances in the womb. They may or may not cause health problems later in your pet’s life. They are rare, but important to consider, if your dog has urinary tract problems.   Disorders of the Kidneys There are many congenit
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Detecting Disorders of the Kidneys and Urinary Tract in Dogs
date February 3, 2025
Your veterinarian can diagnose many common problems with the urinary system by taking a history of how your dog has acted in the days prior to its becoming sick, performing a physical examination, and performing tests on the dog’s blood and urine. The history that your veterinarian takes might include information regarding changes in how much water your pet drinks, how often it urinates, how much urine it produces, how the urine looks, and how your pet behaves. Your veterinarian
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The Urinary System of Dogs
date January 31, 2025
The urinary system or tract includes the kidneys, the ureters (tubes that connect the kidneys to the bladder), the b
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Gammopathies in Dogs
date January 31, 2025
The body sometimes produces too many antibodies (immunoglobulins). Gammopathies are conditions in which there is a dramatic rise in the production of antibodies. There are 2 general types: polyclonal and monoclonal. In polyclonal gammopathies, levels of all the major immunoglobulins are increased. In monoclonal gammopathies, the levels of only a single type of immunoglobulin are increased. Polyclonal gammopathies may occur whe
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Immune System Tumors in Dogs
date January 31, 2025
Cancer occurs when cells grow out of control. This can happen with the cells of the immune system. The tumor cells do not usually perform normal functions, which leads to immunodeficiencies. The normal immune system requires a rapid increase in the growth of lymphocytes to fight foreign invaders. On occasion however, this increase in the growth of lymphocytes may be uncontrolled and can lead to the production of mutated cells, which
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Immune-deficiency Diseases in Dogs
date January 31, 2025
Immune-deficiency diseases have serious consequences and often lower the body’s defenses against infection. Some are inherited, and others are caused by viral infections or cancer.   Deficiencies in Phagocytosis Phagocytosis is an essential mechanism of the immune system. Phagocytes are cells that engulf (phagocytize), digest, and kill foreign invaders. Phagocytes rapidly respond to infections as part of th
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Disorders Involving Cell-mediated Immunity (Type IV Reactions) in Dogs
date January 31, 2025
This type of reaction occurs when specific types of white blood cells (called T helper cells) respond to antigens and release toxic and inflammatory substances that can damage tissues. Cell-mediated immune reactions can occur in any organ. Treatment usually involves eliminating the offending antigen (if possible) and the use of anti-inflammatory drugs and drugs that suppress the immune system, either alone or in combination.  
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Disorders Involving Immune Complexes (Type III Reactions) in Dogs
date January 31, 2025
When antibodies bind to persistent antigens, they can create immune complexes. These antigen-antibody complexes can get lodged in small blood vessels and stimulate inappropriate inflammation of the surrounding tissue. Immune complex disorders are among the most common immune-mediated diseases. The location in the body where the immune complexes are deposited determines the signs and the course of the disease.   Glomerulonephritis
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Disorders Involving Cytotoxic Antibodies (Type II Reactions) in Dogs
date January 31, 2025
Type II reactions occur when an antibody binds to an antigen present at the surface of its own cells. These reactions can lead to several types of diseases in dogs, including anemia, blood clotting problems, and skin and muscle disorders. They may be associated with other immune system disturbances, such as systemic lupus erythematosus, or triggered by a drug, vaccine, or infection. Most often, the triggering cause cannot be pinpointed. Immune-mediated hemolytic anem
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Disorders Involving Anaphylactic Reactions (Type I Reactions, Atopy) in Dogs
date January 31, 2025
In a Type I reaction, the animal has been previously exposed to an antigen and produces an excess of antibodies. If this antigen appears in the blood, the reaction can be either body-wide (such as anaphylactic shock) or localized (such as itchy patches on the skin). If the antigen enters through the skin, a localized reaction is more common.   Anaphylactic Shock Anaphylactic shock
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